Knee Cartilage Repair with Stem Cells Treatment
- 44 Million Mesenchymal Stem Cells mixed with Platelet Rich Plasma (PRP) is Injected into the knee joint
- An IV of 100 Million Mesenchymal Stem Cells is administered after the knee injection
- Lyophilized Placenta is mixed with saline solution and injected subcutaneously
The Knee Cartilage Repair with Stem Cells treatment takes about 3 hours to complete. We add the 100 million stem cell IV to this treatment because it allows us to treat the cartilage via the bloodstream. Cartilage is not able to regenerate when there is not enough blood flow to the area. Mesenchymal stem cells and PRP are able to release Vascular endothelial growth factor (VEGF). VEGF helps the body to create new blood vessels. Since the stem cells target inflammation they will go to the cartilage and release the VEGF to help create new blood flow. This new blood flow will allow the cartilage to regrow. We have seen lots of success with cartilage damage in knees from just the intra-articular injections, but when we add the IV the repair is much faster.
We Perform the Knee and IV Stem Cell Treatments Tuesday through Saturday. This is because the lab only cultivates the mesenchymal stem cells Monday through Thursday. The Stem Cells are suspended in Sodium Lactate and never frozen. This means they are only viable for 4 days after cultivation and we prefer to get them into patients within 48 hours.
Why do we need Mesenchymal Stem Cells for Knee Repair?
We need more stem cells as we age, but our body is using them up. When we are infants, we have the most stem cells that we will ever have and then by the time we grow up to bone maturity, we only have 10% of these cells left. Only 10% and that is all we have left to work with for the rest of our lives. Cells die off as we age and that percentage goes down even further every year. Your knees are greatly effected by fewer stem cells in your system. Scarring in the knee area, cartilage loss and ligament issues all contribute to knee issues. Your body wants to repair your knees, but scarring and lack of stem cells prevents it.
So How does Knee Cartilage Repair with Stem Cells work?
Knee Cartilage Repair with Stem Cells work by stimulating the body to regenerate itself. Their magic is not in their ability to become or replace different tissues or cells, but in their production of trophic factors, bioactive molecules produced in response to the environment in which the cells are in. These secreted chemicals aid in repairing tissue and the recruitment of new blood vessels to support nutrient flow to the area and decrease inflammation. By repairing tissue, recruiting new blood vessels and increased nutrient flow your body will start to behave the way it did in your early 20’s. This means knees that flow like a 20 year old. So it is not the cells themselves that work the magic. It is what the cells secrete that has such anti-aging and medicinal potential.
Immune Response Issues Causing Knee Issues
Your body is amazing at regenerating and it wants to repair your knees. The problem is that damage and scarring occur at the area when the immune system doesn’t work exactly like it should from a lack of stem cells. So we get these stem cells into your knees and they allow the T Cells to protect the area of inflammation, but without attacking the area. The mesenchymal stem cells secretions influence the immune system to eliminate some of the scarring which then allows the knee to repair. The Platelette Rich Plasma (PRP) is injected with the stem cells to provide ample growth factors that aid in regeneration.
More info on the Mesenchymal Stem Cell Secretions
Mesenchymal Stem cells (MSCs) secrete a wide range of cellular products, molecules, exosomes (part of the genome thats inside RNA. Progams protein coding) and microvesicles ( Microvesicles play a role in intercellular communication and can transport mRNA, miRNA, and proteins between cells.) That act in different ways to stimulate the body’s healing process.
Growth Factors Aid in Knee Repair
Growth factors (A growth factor is a naturally occurring substance capable of stimulating cellular growth, proliferation, healing, and cellular differentiation. Usually it is a protein or a steroid hormone. Growth factors are important for regulating a variety of cellular processes. This is why we add platelette rich plasma (PRP). The PRP adds your bodies own growth factors to the area in high concentrations.
Cytokines (Cytokines are a broad and loose category of small proteins that are important in cell signaling. Their release has an effect on the behavior of cells around them. It can be said that cytokines are involved in autocrine signaling, paracrine signalingand endocrine signaling as immunomodulating agents.) , hormones, and cellular mitochondria and RNA are among the secreted bioactive molecules and cellular material that characterize the wide range of activities carried out by mesenchymal stem cells. When considering that the main function of stem cells lies in their secretome. This is the bioactive molecules they secrete. This means they don’t have the ability to differentiate into new tissue, but instead allow your own body to heal itself properly. Isolating these trophic factors separate from the cells offers an intriguing mode of treatment.
How Soon Will My Knees Feel Better?
Most Patients will start to see results immediately. Just having extra fluid in the area from the injection has most people feeling better the day of the procedure. The real healing results typically set in around the 1 month mark. For more severe cartilage damage it can take months. The IV added to this treatment means that most people will start to see a lot of relief at the 1 month mark post treatment.
Do the Stem Cell + PRP Treatment Results Last?
The results from Stem Cell knee repair plus PRP Treatment are lasting because your body is able to heal itself like when you were younger. That healing does not go away fast, just think of how many years it took to get you where you are. This protocol includes our Anti-Aging Stem Cell protocol for continued care.
Stem Cell Knee Treatment Videos
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