{"id":13720,"date":"2022-10-01T16:12:43","date_gmt":"2022-10-01T16:12:43","guid":{"rendered":"https:\/\/dreambody.clinic\/?page_id=13720"},"modified":"2022-10-01T16:12:45","modified_gmt":"2022-10-01T16:12:45","slug":"mesenchymal-stem-cells-transplantation-for-systemic-lupus-erythematosus-study","status":"publish","type":"page","link":"https:\/\/dreambody.clinic\/demo\/mesenchymal-stem-cells-transplantation-for-systemic-lupus-erythematosus-study\/","title":{"rendered":"Mesenchymal stem cells transplantation for systemic lupus erythematosus Study"},"content":{"rendered":"\n<p>Mesenchymal stem cells transplantation for systemic lupus erythematosus Study<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-abstract\">Abstract<\/h2>\n\n\n\n<p>Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease, which, despite the advances in immunosuppressive medical therapies, remains potentially fatal in some patients, especially in treatment-refractory patients. This study found that transplantation of umbilical cord mesenchymal stem cells (UC-MSCs) has the same therapeutic effect as transplantation of bone marrow mesenchymal stem cells (BM-MSCs), which has been reported to be efficient in treating SLE-related symptoms in MRL\/lpr mice. Multi-treatment (at the 18th, 19th, and 20th weeks of age) of 1 \u00d7 10<sup>6<\/sup>\u00a0UC-MSCs was able to decrease the levels of 24-h proteinuria, serum creatinine, and anti-double-stranded DNA (dsDNA) antibody, and the extent of renal injury such as crescent formation in MRL\/lpr mice. A lower, but still significant, reduction in these parameters was also observed in mice receiving a single dose of UC-MSCs (at the 18th week). UC-MSCs treatment also inhibited expression of monocyte chemotactic protein-1 (MCP-1) and high-mobility group box 1 (HMGB-1) expression in a similar fashion. UC-MSCs labeled with carboxyfluorescein diacetate succinimidyl ester (CFSE) were found in the lungs and kidneys 1 week post infusion. In addition, after 11 weeks post UC-MSCs infusion, human cells were found in kidney of UC-MSCs-treated mice. These findings indicated that UC-MSCs transplantation might be a potentially promising approach in the treatment of lupus nephritis, possibly by inhibiting MCP-1 and HMGB-1 production. Lupus (2010) 19, 1502\u20141514.<\/p>\n\n\n<div class=\"wp-block-pdfemb-pdf-embedder-viewer\"><a href=\"https:\/\/dreambody.clinic\/demo\/wp-content\/uploads\/2022\/10\/Transplantation-of-Umbilical-cord-MSCs-alleviates-lupus-nephritis.pdf\" class=\"pdfemb-viewer\" style=\"\" data-width=\"max\" data-height=\"max\" data-toolbar=\"bottom\" data-toolbar-fixed=\"off\">Transplantation-of-Umbilical-cord-MSCs-alleviates-lupus-nephritis<\/a><\/div>\n<p class=\"wp-block-pdfemb-pdf-embedder-viewer\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Mesenchymal stem cells transplantation for systemic lupus erythematosus Study Abstract Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease, which, despite the advances in immunosuppressive medical therapies, remains potentially fatal in some patients, especially in treatment-refractory patients. This study found that transplantation of umbilical cord mesenchymal stem cells (UC-MSCs) has the same therapeutic effect as&hellip;<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"rs_blank_template":"","rs_page_bg_color":"","slide_template_v7":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-13720","page","type-page","status-publish","hentry","description-off"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.2 (Yoast SEO v27.6) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Mesenchymal stem cells transplantation for systemic lupus erythematosus Study - Dream Body Clinic Stem Cell Therapy Puerto Vallarta Mexico 2026 &amp; HGH<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Mesenchymal stem cells transplantation for systemic lupus erythematosus Study\" \/>\n<meta property=\"og:description\" content=\"Mesenchymal stem cells transplantation for systemic lupus erythematosus Study Abstract Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease, which, despite the advances in immunosuppressive medical therapies, remains potentially fatal in some patients, especially in treatment-refractory patients. 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