{"id":3767,"date":"2021-04-02T20:12:59","date_gmt":"2021-04-02T20:12:59","guid":{"rendered":"https:\/\/dreambody.clinic\/?page_id=3767"},"modified":"2024-04-01T01:47:14","modified_gmt":"2024-04-01T01:47:14","slug":"mesenchymal-stem-cell-released-paracrine-factor-mediating-myocardial-survival-and-repair","status":"publish","type":"page","link":"https:\/\/dreambody.clinic\/demo\/mesenchymal-stem-cell-released-paracrine-factor-mediating-myocardial-survival-and-repair\/","title":{"rendered":"mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\" id=\"h-mesenchymal-stem-cell-released-paracrine-factor-mediating-myocardial-survival-and-repair-intro\">mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair Intro:<\/h2>\n\n\n\n<p>Stem cell therapy has emerged as a promising tool for the treatment of a variety of diseases. Previously, we have shown that Akt-modified mesenchymal stem cells mediate tissue repair through paracrine mechanisms. Using a comprehensive functional genomic strategy, we show that secreted frizzled related protein<br>2 (Sfrp2) is the key stem cell paracrine factor that mediates myocardial survival and repair after ischemic injury. Sfrp2 is known<br>to modulate Wnt signaling, and we demonstrate that cardiomyocytes treated with secreted frizzled related protein increase cellular-catenin and up-regulate expression of antiapoptotic genes. These findings reveal the key role played by Sfrp2 in mediating the paracrine effects of Akt-mesenchymal stem cells on tissue repair and identify modulation of Wnt signaling as a therapeutic target for heart disease.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-mesenchymal-stem-cell-released-paracrine-factor-mediating-myocardial-survival-and-repair-full-study\">mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair &#8211; Full Study<\/h2>\n\n\n<div class=\"wp-block-pdfemb-pdf-embedder-viewer\"><a href=\"https:\/\/dreambody.clinic\/demo\/wp-content\/uploads\/2021\/04\/mesenchymal-stem-cell-released-paracrine-factor-mediating-myocardial-survival-and-repair.pdf\" class=\"pdfemb-viewer\" style=\"\" data-width=\"max\" data-height=\"max\" data-toolbar=\"bottom\" data-toolbar-fixed=\"off\">mesenchymal-stem-cell-released-paracrine-factor-mediating-myocardial-survival-and-repair<\/a><\/div>\n<p class=\"wp-block-pdfemb-pdf-embedder-viewer\"><\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"576\" src=\"https:\/\/dreambody.clinic\/demo\/wp-content\/uploads\/2021\/04\/mesenchymal-stem-cell-released-paracrine-factor-mediating-myocardial-survival-and-repair-1024x576.webp\" alt=\"mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair\" class=\"wp-image-3769\" srcset=\"https:\/\/dreambody.clinic\/demo\/wp-content\/uploads\/2021\/04\/mesenchymal-stem-cell-released-paracrine-factor-mediating-myocardial-survival-and-repair-1024x576.webp 1024w, https:\/\/dreambody.clinic\/demo\/wp-content\/uploads\/2021\/04\/mesenchymal-stem-cell-released-paracrine-factor-mediating-myocardial-survival-and-repair-300x169.webp 300w, https:\/\/dreambody.clinic\/demo\/wp-content\/uploads\/2021\/04\/mesenchymal-stem-cell-released-paracrine-factor-mediating-myocardial-survival-and-repair-768x432.webp 768w, https:\/\/dreambody.clinic\/demo\/wp-content\/uploads\/2021\/04\/mesenchymal-stem-cell-released-paracrine-factor-mediating-myocardial-survival-and-repair-600x338.webp 600w, https:\/\/dreambody.clinic\/demo\/wp-content\/uploads\/2021\/04\/mesenchymal-stem-cell-released-paracrine-factor-mediating-myocardial-survival-and-repair.webp 1280w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair Intro: Stem cell therapy has emerged as a promising tool for the treatment of a variety of diseases. Previously, we have shown that Akt-modified mesenchymal stem cells mediate tissue repair through paracrine mechanisms. Using a comprehensive functional genomic strategy, we show that secreted frizzled related&hellip;<\/p>\n","protected":false},"author":1,"featured_media":3769,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"rs_blank_template":"","rs_page_bg_color":"","slide_template_v7":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-3767","page","type-page","status-publish","has-post-thumbnail","hentry","description-off"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.2 (Yoast SEO v27.6) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair - Dream Body Clinic Stem Cell Therapy Puerto Vallarta Mexico 2026 &amp; HGH<\/title>\n<meta name=\"description\" content=\"mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair. congestive heart failure stem cell treatment\" \/>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair\" \/>\n<meta property=\"og:description\" content=\"mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair. congestive heart failure stem cell treatment\" \/>\n<meta property=\"og:url\" content=\"https:\/\/dreambody.clinic\/demo\/mesenchymal-stem-cell-released-paracrine-factor-mediating-myocardial-survival-and-repair\/\" \/>\n<meta property=\"og:site_name\" content=\"Dream Body Clinic Stem Cell Therapy Puerto Vallarta Mexico 2026 &amp; 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