{"id":3771,"date":"2021-04-02T20:21:48","date_gmt":"2021-04-02T20:21:48","guid":{"rendered":"https:\/\/dreambody.clinic\/?page_id=3771"},"modified":"2024-04-01T01:46:51","modified_gmt":"2024-04-01T01:46:51","slug":"exosome-secreted-by-msc-reduces-myocardial-ischemia-reperfusion-injury","status":"publish","type":"page","link":"https:\/\/dreambody.clinic\/demo\/exosome-secreted-by-msc-reduces-myocardial-ischemia-reperfusion-injury\/","title":{"rendered":"Exosome secreted by MSC reduces myocardial ischemia\/reperfusion injury"},"content":{"rendered":"\n

Exosome secreted by MSC reduces myocardial ischemia\/reperfusion injury Intro:<\/strong><\/h2>\n\n\n\n

Exosome secreted by MSC reduces myocardial ischemia\/reperfusion injury<\/strong> Abstract: Human ESC-derived mesenchymal stem cell (MSC)-conditioned medium (CM) was previously shown to mediate cardioprotection during myocardial ischemia\/reperfusion injury through large complexes of 50\u2013100 nm. Here we show
that these MSCs secreted 50- to 100-nm particles. These particles could be visualized by electron microscopy and
were shown to be phospholipid vesicles consisting of cholesterol, sphingomyelin, and phosphatidylcholine. They contained
coimmunoprecipitating exosome-associated proteins, e.g., CD81, CD9, and Alix. These particles were purified as a homogeneous
population of particles with a hydrodynamic radius of 55\u201365 nm by size-exclusion fractionation on a HPLC. Together these
observations indicated that these particles are exosomes. These purified exosomes reduced infarct size in a mouse model of
myocardial ischemia\/reperfusion injury. Therefore, MSC mediated its cardioprotective paracrine effect by secreting exosomes.
This novel role of exosomes highlights a new perspective into intercellular mediation of tissue injury
and repair, and engenders novel approaches to the development of biologics for tissue repair.<\/p>\n\n\n\n

\nhttps:\/\/dreambody.clinic\/demo\/index.php\/product\/congestive-heart-failure-stem-cell-treatment\/\n<\/div><\/figure>\n\n\n\n

Exosome secreted by MSC reduces myocardial ischemia\/reperfusion injury<\/strong> – Full Study<\/h2>\n\n\n
Exosome-secreted-by-MSC-reduces-myocardial-ischemia-reperfusion-injury<\/a><\/div>\n

<\/p>\n\n\n\n

\"Exosome<\/figure>\n","protected":false},"excerpt":{"rendered":"

Exosome secreted by MSC reduces myocardial ischemia\/reperfusion injury Intro: Exosome secreted by MSC reduces myocardial ischemia\/reperfusion injury Abstract: Human ESC-derived mesenchymal stem cell (MSC)-conditioned medium (CM) was previously shown to mediate cardioprotection during myocardial ischemia\/reperfusion injury through large complexes of 50\u2013100 nm. Here we showthat these MSCs secreted 50- to 100-nm particles. These particles could…<\/p>\n","protected":false},"author":1,"featured_media":3773,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"rs_blank_template":"","rs_page_bg_color":"","slide_template_v7":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-3771","page","type-page","status-publish","has-post-thumbnail","hentry","description-off"],"yoast_head":"\nExosome secreted by MSC reduces myocardial ischemia\/reperfusion injury - Dream Body Clinic Stem Cell Therapy Puerto Vallarta Mexico 2026 & HGH<\/title>\n<meta name=\"description\" content=\"Exosome secreted by MSC reduces myocardial ischemia - reperfusion injury. 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