Albuterol Syrup for Endurance

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Albuterol Syrup for Endurance and Sports Performance

Albuterol a powerful endurance enhancer and fat-burning agent known well by performance athletes. Most people are familiar with albuterol inhalers for asthma, but systemically albuterol is one of the most used performance enhancing drugs in the sports world.

How Does Albuterol Work for Sports Performance?

Albuterol (Salbutamol for non-USA residents) is a bronchodilator (i.e. relaxes/opens up the airways and makes breathing easier) that is primarily used to treat asthma, bronchospasm, and Chronic Obstructive Pulmonary Disease (COPD). By opening up the airway in a fast acting manner, albuterol allows the user to get more air into the lungs. This improves endurance and physical performance.

In both healthy men and women, the same group of researchers found that short-term or chronic administration of 12 mg Albuterol per day increased maximal anaerobic power, regardless of training status.

In a 2005 study examining Albuterol use (16 mg/day) in weeks 2-3 of a 14-week resistance exercise program, the drug lead to greater strength gains and a higher lean body mass compared to placebo.

A 1997 literature review of performance-enhancing drugs dug up the following studies on beta-2 agonists:

Martineau et al. [1992] examined the effect of 14 and 21 days of treatment with salbutamol 8mg twice daily on strength in 12 healthy men… there was a significant improvement in strength for the hamstring muscle and quadriceps muscle but not for hand grip muscles… the average strength improvement was about 10 to 15%”

Caruso et al. [1995] examined the effect of albuterol 16 mg/day or placebo ingested for 6 weeks. Participants were placed on a 9-week isokinetic strength training programme for the knee extensors. Most measures of strength showed a greater increase on the drug than the placebo.”

Bedi [1988] found that aerosol salbutamol 180 mcg improved cycling sprint time following a 1-hour ride in 3 of the 15 individuals tested. Participants had different levels of training, including highly trained cyclists, triathletes, untrained individuals and recreational athletes. The amount of improvement ranged from 4 to 178 seconds over that of the placebo. If the outliers were discounted, the difference between the placebo and the drug was not significant.”

Signorile et al. [1992] reported that albuterol 180mcg inhaled resulted in an increase in peak power during sprint cycling in nonathletes.”

In a 2000 study involving eight recreational male athletes, short-term use of oral Albuterol use at 12 mg per day “improved performance during intense submaximal exercise.”

And in another 2000 study where non-asthmatic men took 4 mg of oral Albuterol prior to exercising, their mean endurance time and peak torque greatly improved.

Albuterol Anabolic Properties for Building Muscle

Albuterol has actually been shown to help with muscle development. A study involving 65 patients with facioscapulohumeral muscular dystrophy saw muscle volume increases in those who took 16 mg of Albuterol orally per day for 26 weeks.

Albuterol was observed to enhance muscle cell growth during the proliferation stage of skeletal muscle cells, and one experiment conducted on senescent rats saw an increase in skeletal muscle weight for both old and young rats.

In Parkinson’s Disease patients and young boys with Duchenne/Becker muscular dystrophy, 12-16 mg of oral Albuterol per day led to notable increases in lean body mass.

Iron Magazine puts forth a possible explanation for why these observations have taken place:

“Beta-2 adrenoreceptor agonists, such as clenbuterol and albuterol, have been shown to activate cyclic-Adenosine Monophosphate (cAMP). cAMP then activates calpistatin, which inhibits calpain. Calpain degrades protein in muscle tissue. By inhibiting calpain, beta-2 adrenoreceptor agonists have been shown to be anti-catabolic. “

How Does Albuterol Work for Weight Loss?

Albuterol works on fat loss via the adrenergic effect. Adrenergic means:

“[drugs] that mimic or interfere with the functioning of the sympathetic nervous system by affecting the release or action of norepinephrine and epinephrine. These hormones, which are also known as noradrenaline and adrenaline, are secreted by the adrenal gland, hence their association with the term adrenergic.

“…they constrict blood vessels (vasoconstriction), which increases blood pressure, and accelerate the rate and force of contractions of the heart. Adrenergic drugs that produce or inhibit these effects are known as sympathomimetic agents [stimulate the sympathetic nervous system] and sympatholytic agents [inhibit sympathetic nervous system activity], respectively.”

Albuterol is a central nervous system (CNS) stimulant which helps it to increase the persons metabolism and leads to weight loss. For the most in depth analysis of how Albuterol works for weight loss and sports performance then check out Jay Campbell’s post here.

Dream Body Clinic Albuterol dose for maximal fat loss:

3-6 mg taken once per day for two weeks straight (ideally in the early morning before fasted cardio), followed by a two-week “off” period. 

This dosage stays the same whenever you want to shed body fat, but it does come with some caveats:

Go for the lower dosing range if you’re below 200 pounds, and the higher dosing range if you’re over 200 pounds

Albuterol’s ability to mobilize stubborn fat tissue is best when used during its short half-life of 4-6 hours, hence why we recommend timing it in the morning before fasted cardio and before eating to maximize absorption (additionally, a high-fat diet inflames the airway of asthma patients)

Albuterol also functions best in a low insulin environment, so ideally you want to be 15% body fat or lower when you start using it (fat people have impaired “beta(2)-adrenoceptor-mediated increases in thermogenesis” and “local lipolysis“)

The “two week on, two week off” cycle is recommended because the body quickly develops a tolerance to Albuterol (i.e. Albuterol down regulates the beta-2 receptors and thus its effectiveness decreases over time)

The oral formulation was most extensively studied in humans for its benefits on metabolic rate and exercise performance. 

You’ll notice on most forums that many people use Albuterol at 2-4 mg per dose for a total of 3-4 doses per day (6-16 mg total per day) — this is FAR beyond what I have ever used, so it’s up to you to experiment and see what works best for you.

Finally… there’s a notable thermogenic effect when Albuterol is combined with coffee and/or nicotine,

Feel free to experiment with combining to see what gives you the desired effects without the side effects I’m about to mention.

Albuterol Side Effects & Safety Profile

If you follow my dosing and cycling recommendations, the side effects of Albuterol are both mild and rare.

Some of the most commonly reported Albuterol side effects include:

  • Nausea
  • Headache
  • Involuntary shaking of hands/feet
  • Nervousness
  • Muscle aches

Watch out for undesirable drug-drug interactions with Albuterol, such as diuretics, beta-blockers, tricyclic antidepressants, monoamine oxidase inhibitors, and other short-acting bronchodilators.

Two precautions you may want to take are the following, as suggested by other performance enhancement enthusiasts:

  • Ketofin supplementation — 1-2 mg of this anti-histamine drug alongside Albuterol for 7 days reportedly up regulates beta-2 receptors when they are down regulated, allowing for extended use of Albuterol (although you should never use it for longer than 8 weeks)
  • Taurine supplementation — regular Albuterol use reportedly leads to loss of taurine, which may cause excessive and/or severe muscle pumps. 3-5 grams of Taurine per day is recommended to fix this issue.

One of the largest Reddit threads on Albuterol provides a good balance of benefits and risks associated with using the agent for bodybuilding purposes, so I’ll summarize the main takeaways below:

  • Positives
    • Works as promised for fat loss
    • Muscle preservation with a slight anabolic effect
    • “Pre-workout like effect” that translates to more energy during a workout and new PRs
  • Negatives
    • Shakiness / jitters
    • Anxiety attack
    • Slight increase in heart rate

Albuterol is considered a banned substance by the World Anti-Doping Association so semi-professional or professional athletes should take note.

Ventolin Albuterol Syrup 100ml 0.04g