5 year study of stem cells for heart regeneration

5 year study of stem cells for heart regeneration PDF above and text below. EvolutionofleftventricularfunctionafterWharton’sjellymesenchymalstemcellstranscoronary administration:5-yearfollowupinapilotcohortofCIRCULATE-AMIRandomizedTrial E.Kwiecien1,L.Drabik2,A.Mazurek1,M.Sikorska1,L.Czyz1,M.Skubera1,M.Urbanczyk3,W.Szot4,M.Kostkiewicz5,R.P.Banys3,W.Plazak1, M.Olszowska1,M.Majka6,P.Podolec1,P.Musialek1 1JagiellonianUniversity,JohnPaul IIHospital,DeptofCardiac&VascularDiseases,Krakow,Poland;2JagiellonianUniversity,Departmentof Farmacology,JohnPaul IIHospital,DeptofCardiac&VascularDiseases,Krakow,Poland;3JohnPaul IIHospital,DeptofRadiology,Magnetic ResonanceImagingLaboratory,Krakow,Poland;4JohnPaul IIHospital,DepartmentofNuclearMedicine,Krakow,Poland;5JagiellonianUniversity, JohnPaul IIHospital,DeptofCardiac&VascularDiseases,DeptNuclearMedicine,Krakow,Poland;6JagiellonianUniversity,Deptof Transplantation,Krakow,Poland OnbehalfofCIRCULATE FundingAcknowledgement:Typeoffundingsource:Publicgrant(s)–Nationalbudgetonly.Mainfundingsource(s):STRATEGMED265761 “CIRCULATE”NationalCentreforResearchandDevelopment/Poland/ZDS/00564JagiellonianUniversityMedicalCollege Introduction:CIRCULATE-AcuteMyocardial Infarction isadouble-blind controlledtrial randomizing(RCT) in105consecutivepatientswiththeir first, largeAMI (cMRI-LVEF≤45%and/orcMRI-infarctsize≥10%ofLV) withsuccessful infarct-relatedartery(IRA)primarypercutaneouscoronary intervention(pPCI)totranscoronaryadministrationofWharton’sJellyMesenchymalStemCells(WJMSCs)vs.placebo(2:1).Thepilotstudycohort (PSC)precededtheRCT. Aim: To evaluateWJMSCs long-term safety, and evolution of leftventricular(LV)functioninCIRCULATE-AMIPSC. Materialandmethods:30000000WJMSCs(50%labelledwith99mTcexametazime)wereadministeredviaIRAinaten-patientPCS(age32–65 years,peakhs-TroponinT17.3±9.1ng/mLandpeakCK-MB533±89U/L,…