5 year study of stem cells for heart regeneration

5 year study of stem cells for heart regeneration PDF above and text below. EvolutionofleftventricularfunctionafterWharton’sjellymesenchymalstemcellstranscoronary administration:5-yearfollowupinapilotcohortofCIRCULATE-AMIRandomizedTrial E.Kwiecien1,L.Drabik2,A.Mazurek1,M.Sikorska1,L.Czyz1,M.Skubera1,M.Urbanczyk3,W.Szot4,M.Kostkiewicz5,R.P.Banys3,W.Plazak1, M.Olszowska1,M.Majka6,P.Podolec1,P.Musialek1 1JagiellonianUniversity,JohnPaul IIHospital,DeptofCardiac&VascularDiseases,Krakow,Poland;2JagiellonianUniversity,Departmentof Farmacology,JohnPaul IIHospital,DeptofCardiac&VascularDiseases,Krakow,Poland;3JohnPaul IIHospital,DeptofRadiology,Magnetic ResonanceImagingLaboratory,Krakow,Poland;4JohnPaul IIHospital,DepartmentofNuclearMedicine,Krakow,Poland;5JagiellonianUniversity, JohnPaul IIHospital,DeptofCardiac&VascularDiseases,DeptNuclearMedicine,Krakow,Poland;6JagiellonianUniversity,Deptof Transplantation,Krakow,Poland OnbehalfofCIRCULATE FundingAcknowledgement:Typeoffundingsource:Publicgrant(s)–Nationalbudgetonly.Mainfundingsource(s):STRATEGMED265761 “CIRCULATE”NationalCentreforResearchandDevelopment/Poland/ZDS/00564JagiellonianUniversityMedicalCollege Introduction:CIRCULATE-AcuteMyocardial Infarction isadouble-blind controlledtrial randomizing(RCT) in105consecutivepatientswiththeir first, largeAMI (cMRI-LVEF≤45%and/orcMRI-infarctsize≥10%ofLV) withsuccessful infarct-relatedartery(IRA)primarypercutaneouscoronary intervention(pPCI)totranscoronaryadministrationofWharton’sJellyMesenchymalStemCells(WJMSCs)vs.placebo(2:1).Thepilotstudycohort (PSC)precededtheRCT. Aim: To evaluateWJMSCs long-term safety, and evolution of leftventricular(LV)functioninCIRCULATE-AMIPSC. Materialandmethods:30000000WJMSCs(50%labelledwith99mTcexametazime)wereadministeredviaIRAinaten-patientPCS(age32–65 years,peakhs-TroponinT17.3±9.1ng/mLandpeakCK-MB533±89U/L,…

5 Year Study of Stem Cells for Heart Regeneration

This 5 year study of stem cells for heart regeneration published in the European Heart Journal, Volume 41, Issue Supplement_2, November 2020, ehaa946.1719, https://doi.org/10.1093/ehjci/ehaa946.1719 shows that umbilical mesenchymal stem cells work for improving left ventricle ejection fraction. This was not the biggest study with only 10 participants, but the results are still amazing. Of the 10…