Alzheimer's Disease Intranasal Mesenchymal Stem Cells Study

At Dream Body Clinic we treat Alzheimer’s Disease, Dementia, and related neurodegenerative conditions with Stem Cell Therapy. For Alzheimer’s and dementia we use 50 million mesenchymal stem cells injected intrathecal (into the spinal fluid). These MSCs travel from the spinal fluid to the cerebral fluid where they can guide the cellular repair of damage from Alzheimer’s and dementia. In view of the rapid preclinical development of cell-based therapies for neurodegenerative disorders, the safe and efficient delivery and targeting of therapeutic cells to the central nervous system is critical. INA of microglia in naive BL/6 mice led to targeted and effective delivery of cells to the brain (up to 2.1 × 10⁴ cells in the brain after INA of 1 × 10⁶ cells). MSCs expressing eGFP were detected in the olfactory bulb, cortex, amygdala, striatum, hippocampus, cerebellum, and brainstem of transgenic mice. Key words: Intranasal; Mesenchymal stem cells (MSCs); Macrophages; Alzheimer’s disease; Parkinson’s disease; Amyloid beta (Aβ).