Mesenchymal Stem Cells Improve Neuropathology and Cognitive Impairment in an Alzheimer’s Disease Study Abstract:
This page is a review of the study, Mesenchymal Stem Cells Improve Neuropathology and Cognitive Impairment in an Alzheimer’s Disease Study. At Dream Body Clinic we deal with Alzheimer’s Disease Dementia and Stem Cell Therapy. For Alzheimer’s and dementia we use 50 million mesenhcymal stem cells that are injected intrathecal (into the spinal fluid). These mesenchymal stem cells are able to travel from the spinal fluid to the cerebral fluid where they can guide the cellular repair of damage from Alzheimer’s and dementia. Learn about Dream Body Clinic Alzheimer’s Stem Cell Treatment Here. This treatment has shown tremendous results in cognition and verbal response in patients. Read the following study to learn more about the deep details of how mesenchymal stem cells can treat Alzheimer’s and Dementia. The following is the Mesenchymal Stem Cells Improve Neuropathology and Cognitive Impairment in an Alzheimer’s Disease Study Abstract.
Human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSC) have a potential therapeutic role in the treatment of
neurological disorders, but their current clinical usage and mechanism of action has yet to be ascertained in Alzheimer’s disease (AD). Here
we report that hUCB-MSC transplantation into amyloid precursor protein (APP) and presenilin1 (PS1) double-transgenic mice significantly
improved spatial learning and memory decline. Furthermore, amyloid- peptide (A) deposition, -secretase 1 (BACE-1) levels, and tau
hyperphosphorylation were dramatically reduced in hUCB-MSC transplanted APP/PS1 mice. Interestingly, these effects were associated
with reversal of disease-associated microglial neuroinflammation, as evidenced by decreased microglia-induced proinflammatory cytokines,
elevated alternatively activated microglia, and increased anti-inflammatory cytokines. These findings lead us to suggest that hUCB-MSC
produced their sustained neuroprotective effect by inducing a feed-forward loop involving alternative activation of microglial neuroinflammation,
thereby ameliorating disease pathophysiology and reversing the cognitive decline associated with A deposition in AD mice.
© 2012 Elsevier Inc. All rights reserved.
Keywords: Alzheimer’s disease; Human umbilical cord blood-derived mesenchymal stem cell; Amyloid-; microglia; Spatial learning and memory;